Here you can view a selection of Research funded by Wellbeing of Women listed by the condition to which it relates.
To view more details, click on the paragraph title.
Safe out-patient treatment by laser of cervical cancer and early detection and treatment of cervical cancer Relevant Research:
1980: Dr Henry Charles Kitchener, Paisley Maternity Hospital; Investigate, at a molecular level the association between herpes virus and carcinoma of the cervix, £10651 over 24 months
1981: Mr Patrick George Walker, Whittington Hospital; A study of non-condylomatous wart virus infection of the uterine cervix and its relationship to cervical intra-epithelial neoplasia; a multidisciplinary study, £22414 over 24 months
1982: Dr William Soutter, University of Sheffield; Nuclear and cytoplasmic oestrogen receptor measurement in squamous carcinoma of the cervix, £16098 over 36 months
1986: Dr Henry Charles Kitchener, University of Glasgow; Molecular studies of the effects exerted by human papillomavirus infection and the oral steroid contraceptive on the normal human cervix, £27191 over 24 months
1989: Professor Victor Tindall, University of Manchester; Cervical intra-epithelial neoplasia (cin): a new diagnostic market & the prospect of automating cervical screening, £35582 over 24 months
1989: Dr Jane Christine Longfield, Queen Elizabeth Hospital Gateshead, The development of a glycoprotein screening technique for cervical cytological abnormalities, £64625 over 24 months
1990: Dr Michael Wells, University of Leeds; Detection and Measurement of Smoking Related DNA Adducts in the Uterine Cervix, £29185 over 24 months
1991: Dr Joan Macnab, University of Glasgow; Cloning and characterisation of a cervical cancer gene, £50871 over 24 months
1991: Dr David Latchman, University College London; Regulation of papillomavirus gene expression in the normal and malignant cervix by a cervical cell-specific cellular transcription factor, £70000 over 36 months
1991: Dr Damian Eustace, St Thomas’ Hospital, London; Growth factors and the interaction between epithelium and stroma in the pathogenesis of neoplasia of the cervix, £63811 over 24 months
1992: Dr Karen Vousdon, Ludwig Institute for Cancer Research; Identification of genetic alterations which contribute to the development of human papillomavirus associated cervical cancer; £73440 over 24 months
1993: Dr Massimo Pignatellli, RPMS Hammersmith Hospital, London; Cell adhesion molecules in cervical neoplasia, £66123 over 24 months
1993: Dr Adekunle Odunsi, University of Oxford; Immunogenetic analysis of HLA Class II antigens in pre-malignant disease of the cervix and their correlation with HPV status, £61968 over 24 moths
1993: Dr Elizabeth Adams, University of Liverpool; p53 HPV & epidermal growth factor receptor: do they add prognostic information in cervical carcinoma, £32080 over 12 months
1994: Professor David Latchman, University College London; Regulation of papilloma virus gene expression by the antagonistic cervical cell transcription factors Brn-3a and Brn-3b, £74660 over 24 months
1995: Dr Massimo Pignatelli, Hammersmith Hospital London; Genetic modulation of E-cadherin/cantenin expression in cervical epithelial cells, £64552 over 24 months 1996: Dr Charles Herrington, University of Liverpool; Karyotypic analysis of cervical neoplasia: chromosome aberrations and human papillomavirus infection, £50993 over 24 months
1996: Dr Stephen Peter Dobbs, City Hospital Nottingham; The expression of angiogenic and anti-aniogenic factors in the neovascularisation of cervical intraepithelial neoplasia and cervical carcinoma, £33125 over 24 months
1997: Dr Massimo Pignatelli, RPMS Hammersmith Hospital, London; Cross-talk between E-Cadherin /Cantenin complex and epidermal growth factor in promoting invasion in cervical cancer cells, £69457 over 24 months
1997: Professor Eamonn Maher, University of Birmingham; Isolation and characterisation of cervical and ovarian cancer tumour suppressor genes located on chromosome 3, £69395 over 24 months
1998: Professor David Latchman, University College London; Regulation of the HPV- activating transcription factor Brn-3a in normal and malignant cervical cells, £73122 over 24 months
2006: Dr Iain Morgan, University of Glasgow; A therapeutic strategy for improving treatment of virally induced gynaecological cancers, £110071 over 24 months 2007: Dr Innocent Maranga, University of Manchester; Relationship between HIV/AIDS and cervical dysplasia and the role of HAART in the management of cervical dysplasia, £20000 over 12 months
Potential birth abnormalities can be investigated and screened, and known problems such as spina bifida can be prevented by, for example, recommending folic acid be taken during pregnancy Relevant Research:
1975: Miss Lesley Valerie Cooper, Queen Charlotte's Maternity Hospital; Effect of drugs on the fetus and newborn, £5201 over 12 months
1976: Professor Edward Osmund Royle Reynolds, University College Hospital and Medical School; Follow-up Study of children surviving after severe perinatal illness or abnormalities, £16068 over 60 months
1981: Dr Robert John McLelland, Queen’s University Belfast; The Evaluation of a Fully Objective Audiological Screening Technique in Neonates at Risk of Hearing Impairment, £1000 over 24 months
1982: Professor Neville Butler, University of Bristol; Longitudinal analysis of the 1970 birth cohort to assess whether abnormalities of pregnancy, labour or delivery are associated with adverse development in the surviving child, £12896 over 12 months
1984: Dr Arnold Cohen, University College London; Antenatal diagnosis of congenital rubella by identification of rubella RNA sequences, £17971 over 12 months
1984: Dr Doris M. Campbell, University of Aberdeen; A Study of Vitamin Status in Human Pregnancy, £24743 over 24 months
1985: Professor Derek Bryce-Smith, University of Reading; Placental element levels in relation to fetal maldevelopment, £13130 over 24 months
1987: Dr James P Neilson, University of Glasgow; Prospective Randomised Study of Doppler Waveforms in Umbilical and Uterine Arteries as a Screening method to Identify the Compromised Fetus, £23000 over 24 months
1987: Dr Stephen David Macleod Brown, St. Mary's Hospital Medical School University of London; Isolation and characterisation of a gene affecting vertebral segmentation in early mammalian development, £35000 over 24 months
1988: Dr Dulcie Coleman, St. Mary's Medical School London and Queen Charlotte's Maternity Hospital; Evaluation of early amniocentesis for prenatal diagnosis, £37937 over 24 months
1988: Dr Dennis Raymond Burton, University of Sheffield; Hybrid antibodies as therapeutic anti-d reagents for the prevention of haemolytic disease of the newborn, £45285 over 24 months
1990: Dr Gudrun Moore, Queen Charlotte's and Chelsea Hospital; The genetic aetiology of anembryonic pregnancies, £67319 over 36 months
1991: Dr Richard Holliman, St George’s Medical School; The diagnosis of congenital toxoplasmosis, £58282 over 36 months
1992: Mr John Scrimgeour, Western and Eastern General Hospitals, Edinburgh; Detection of fetal genetic abnormality from maternal blood samples, £69517 over 24 months 1993: Mr Timothy Wheeler, University of Southampton; Maternal iron stores and fetal development, £69533 over 24 months
1994: Dr John Wolstenholme; University of Newcastle Upon Tyne; Investigation of the relationship between confined placental mosaicism, uniparental disomy, high and low birthweight infants and adverse pregnancy outcomes, £74869 over 36 months
1995: Professor David Hall, St George’s Hospital London; What proportion of neonatal encephalopathy is due to hypoxic-ischaemic damage?, £5700 over 12 months 1996: Professor Anthony Edwards, Hammersmith Hospital London; Prenatal cerebal injury in preterm infants,£72714 over 24 months
1997: Professor Andrew Copp, Institute of Child Health, London; Inositol - a new method for prevention of spina bifida, £69158 over 24 months
1998: Professor Nicholas Fisk, Imperial College at Queen Charlotte's Hospital, London; Selective enrichment and ex vivo expansion of fetal over maternal haemopoietic stem/progenitor cells for non-invasive prenatal diagnosis, £79635 over 24 months 1999: Professor Andrew Copp, Institute of Child Health, London; Neural tube defects: gene interactions and prevention by vitamins, £78730 over 24 months
2001: Dr Susan Pickering, Guys and St Thomas's Hopsital; An examination of the chromosomes within an embryo, £79516 over 24 months 2001: Dr Graham Burton, University of Cambridge & University College London; Nutrition of the early human fetus, £77063 over 24 months
2004: Professor Nick Fisk, Imperial College London; Intrauterine transplantation of fetal mesenchymal stem cells to correct muscular dystrophy, £99497 over 24 months
2006: Dr Kelly Cohen, University of Leeds; Use of array comparative genomic hybridisation (CGH) in the investigation of fetal abnormality, £20000 over 12 months 2008: Dr Eamonn Sheridan, Leeds Institute of Molecular Medicine; Investigation into the genetics of Cerebral Palsy, £147367 over 36 months
2009: Professor Lesley Regan, Professor Gudrun Moore and collaborators, Imperial College London, Institute of Child Health at University College London, and London maternity units; The Wellbeing of Women Baby Bio Bank, £1500000 over 60 months
Women with recurrent miscarriage have been helped to a successful pregnancy Relevant Research:
1984: Dr Ian Sargent, University of Oxford; Maternal immune reactivity to the fetus in early pregnancy and recurrent miscarriage, £25174 over 24 months
1985: Dr Peter M Johnson, University of Liverpool; Interleukin-2 in Human Pregnancy & Recurrent Spontaneous Miscarriage, £13606 over 12 months
1987: Professor Peter M Johnson, University of Liverpool; Trophoblast recognition in the context of normal pregnancy & unexplained recurrent miscarriage,£28563 over 24 months
1992: Dr Ronald Lamont, Northwick Park Hospital; Prevention of late miscarriage and preterm labour by treating abnormal microbial colonisation of the genital tract, £47982 over 24 months
1996: Professor Lesley Regan, St Mary’s Hospital London, The role of mannose binding protein gene mutations in recurrent miscarriage, £40000 over 24 months
2004: Dr Ashley Moffett, University of Cambridge; Combinations of maternal KIR and fetal HLA-C genes in recurrent miscarriage, £90284 over 24 months
2006: Dr Helena Nik, University of Liverpool; A study to investigate the vasculature of the uterine endometrium and uterine artery blood flow in women with idiopathic recurrent pregnancy loss, £20000 over 12 months
2007: Dr Raj Rai, Imperial College London; Plasminogen activator inhibitor I, polycystic ovaries and recurrent miscarriage, £94944 over 24 months
2008: Dr Judith Bulmer, Institute of Cellular Medicine, Newcastle; Investigation of the role of intrauterine interleukin 8 and interleukin 6 in normal early pregnancy and sporadic miscarriage, £101696 over 36 months
2009: Professor Lesley Regan, Professor Gudrun Moore and collaborators, Imperial College London, Institute of Child Health at University College London, and London maternity units; The Wellbeing of Women Baby Bio Bank, £1500000 over 60 months
Diagnosis and treatment of ovarian cancer has improved greatly, leading to a doubling of the five-year survival rate since 1970 Relevant Research:
1984: Mr Graham Hunter, University of Leeds; The in vitro assessment of adjuvant danazol in the chemotherapy of ovarian cancer, £10200 over 24 months
1988: Dr Joseph Owen, University of Glasgow; Is there a possible role for epidermal growth factor and its receptor in the analysis and treatment of ovarian tumours?, £39773 over 24 months
1989: Dr Ian Jacobs, The London Hospital; A multimodal approach to screening for ovarian cancer, £68436 over 36 months
1992: Professor Bruce Ponder, University of Cambridge; Identification of specific chromosomal breakpoints in ovarian cancer by chromosome painting, £55995 over 24 months
1992: Mr David Luesley, Dudley Road Hospital Birmingham, University of Birmingham; The effect of surgical intervention on the growth of dynamics of epithelial ovarian cancer, £53000 over 24 months
1992: Dr Trivadi Sundaram Ganesan, John Radcliffe Hosp. University of Oxford; Genetic analysis of tumour progression in epithelial ovarian cancer, £58415 over 36 months
1993: Mrs Karina Reynolds, Kings College School of Medicine/Dentistry; Angiogenic factor expression in ovarian cancer, £77164 over 36 months
1994: Professor Stephen Smith, University of Cambridge; Wellbeing Centre for Ovarian Cancer, £750000 over 60 months
1994: Mr Panayotis Sarhanis, North Staffordshire and Keele University; Molecular Genetic Studies in Ovarian Cancer, £58758 over 24 months
1994: Dr Ian Garth Campbell, University of Southampton; Genetic alteration in early ovarian cancer, £74238 over 24 months
1995: Mr William Roy, Emory Univerity School, Atlanta; Allelotype analysis of benign and borderline ovarian tumours
1995: Dr Ian Duncan, University of Dundee; Identification of novel drug resistance genes in ovarian cancer,
1997: Professor Eamonn Maher, University of Birmingham; Isolation and characterisation of cervical and ovarian cancer tumour suppressor genes located on chromosome 3, £69395 over 24 months
1997: Dr Nina Hallowell, University of Cambridge; The psychological implications of prophylactic oopherectomy for premenopausal women with a family history of ovarian cancer, £62950 over 24 months
1997: Mr Mark Charnock, John Radcliffe Hospital, Oxford; Isolation of a putative tumour suppressor gene on chromosomal arm 6q27 in epithelial ovarian cancer, £38000 over 24 months
1998: Dr Sarah Russell, Queen’s University Belfast; Cloning of a tumour suppressor gene from distal chromosome 17q involved in ovarian malignancy, £79896 over 24 months
1998: Professor Eamonn Maher, University of Birmingham; Molecular genetic investigation of a novel form of microsatellite instability in ovarian cancer, £68740 over 24 months
2000: Professor Bruce Ponder, University of Cambridge; Can a gene profile of individual ovarian cancers indicate the best choice of treatment for each patient? , £133153 over 36 months
2002: Professor Bruce Ponder, University of Cambridge; Are there interactions between the genetic make-up of an individual and specific factors in the environment that determine risk of ovarian cancer, and can this knowledge be used in prevention? , £133153 over 36 months
2005: Dr Paul Pharoah, University of Cambridge; An international collaboration of ovarian cancer case-control studies for use in genetic associated studies, £71931 over 24 months
2005: Dr Joanne Morrison, University of Oxford; Targeting adenoviral suicide gene therapy to intraperitoneal ovarian cancer, £118878 over 24 months
2006: Dr Hillary Russell, Queen’s University Belfast; Clinical relevance of SEPT9 expression in sporadic ovarian cancer and the effect of its modulation on tumour associated phenotypes, £124090 over 36 months
2006: Miss Esther Moss, Keele University; Use of functional cloning to identify genes that confer resistance to platinum based therapy in ovarian epithelial cells affected by cancer, £101666 over 24 months
2006: Dr Iain Morgan, University of Glasgow; A therapeutic strategy for improving treatment of virally induced gynaecological cancers, £110071 over 24 months 2007: Dr Joanne Morrison, University of Oxford; Development of an antibody-resistant adenovirus for virotherapy of ovarian cancer, £123513 over 36 months
2009: Dr Sarah-Jane Lam, Imperial College, Hammersmith Hospital Campus; To investigate the expression of Larp1 protein in ovarian cancer before and after the development of chemotherapy resistance, £20000 over 12 months
2010: Dr Yee-Loi Wan, University of Manchester; An Investigation of adiponectin and adiponectin receptors in ovarian and endometrial cancers, £10375 over 12 months 2011: Dr Sarah Blagden, Imperial College London; Larp1, EMT and chemotherapy resistance in ovarian cancer, £183855 over 36 months
We have increased understanding of Polycystic ovary syndrome (PCOS), improved treatments and enabled better management of the condition Relevant Research:
1988: Dr Stephen Franks, St Mary’s Hospital Medical School; Diet, androgens and polycystic ovary syndrome, £39912 over 24 months
1997: Professor Stephen Franks, Imperial College; Polycystic ovary syndrome and gestational diabetes, £74995 over 24 months
2000: Dr Jane Robinson, Babraham Institute, Cambridge and St Mary's Hospital; Hypothalamic-pituitary disfunction in polycystic ovary syndrome (PCOS), £78147 over 24 months
2007: Professor Stephen Franks, Imperial College London; Insulin resistance in the polycystic ovary; implications for fertility and long-term health, £97360 over 24 months
2009: Dr Adam Kay, Royal Free and University College Medical School; Properties of the Umbilical Artery in Babies born to Mothers with Polycystic Ovary Syndrome, £14655 over 12 months
We have a better understanding of endometriosis, improving diagnosis and treatment and bringing us closer to a cure Relevant Research:
1990: Mr Christopher Sutton, Royal Surrey County Hospital Guildford; Prospective, randomised, controlled trial of treatment of endometriosis with CO2 laser laparoscopy, £19524 over 36 months
1995: Mr Christopher Sutton, Royal Surrey County Hospital Guildford; Prospective, randomised, double-binded controlled trial of laproscopic laser uterine nerve albation in the treatment of pelvic pain associated with endometriosis, £53434 over 24 months
1996: Dr Ian Campbell, University of Southampton; The role of molecular genetic alteration of tumour suppressor genes in the pathogenesis of endometriosis, £60750 over 24 months
1997: Dr Stephen Charnock-Jones, University of Cambridge; Serial analysis of gene expression (SAGE) in the endometrium, £44223 over 24 months
1999: Mr Stephen Kennedy, University of Oxford; Mapping and identifying somatic mutations in deeply infiltrating and ovarian endometriosis, and testing these loci as candidates for endometriosis predisposition genes, £79268 over 30 months
2000: Dr Cristin Print, University of Cambridge; Endometrial regulation of endothelial cell gene expression and function in endometriosis, £78055 over 24 months
2009: Dr Dharani Hapangama, University of Liverpool; The role of the identified regulators of cell fate (RCF) and metastasis-inducing-proteins (MIP) in endometrial steam/progenitor cells (SPC) in endometriosis, £149247 over 36 months
We are improving understanding of and treatment for incontinence and freeing more and more people from this often traumatic condition Relevant Research:
1982: Dr John Richard Sutherset, University of Liverpool; A hydrogel prosthesis for the treatment of stress urinary incontinence in women, £1900 over 1 month
1983: Dr Anthony Smith, St Mary’s Hospital, Manchester; Research Project into the Aetiology of Central Tract Prolapse and Stress Incontinence of Urine, £37428 over 24 months
1994: Mr Paul Hilton, University of Newcastle upon Tyne/Royal Victoria Infirmary; Ambulatory bladder pressure monitoring in asymptomatic & stress incontinent women; the relevance of variables of filling & voiding cystometry to surgical treatment, £34219 over 12 months
1995: Dr Don Wilson, University of Otago; Postnatal incontinence - a multi centre randomised controlled trial of treatment for a common problem, £11823 over 24 months
1995: Mr David John Griffiths, St James’ University Hospital, Leeds; Understanding the pathophysiology of genuine stress incontinence: Imaging of the pelvic floor with a fast scan interventional magnetic resonance imaging machine,
1995: Dr Peter Blakeman, University of Newcastle Upon Tyne; Localisation and quantification of steroid hormone receptors in the female urinary tract; their relationship to oestrogen status and urinary incontinence, £72996 over 24 months
1997: Mr Robert Freeman, Derriford Hospital, Plymouth; Prevention of postpartum stress incontinence by antenatal physiotherapy in at-risk primigravidae: a prospective, randomised controlled trial, £51844 over 24 months
2006: Dr Catherine Glazener, University of Aberdeen; The effect of childbirth on women’s health: urinary and faecal incontinence and prolapsed, £109,579 over 24 months
2008: Dr Douglas Tincello, University of Leicester; Randomised placebo controlled trial of botulinum toxin A for detrusor overactivity in women, £103993 over 84 months
2009: Dr Evangelia Bakali, University of Leicester; Distribution and expression of cannabinoid receptors in human and rodent bladders and action upon pre- and post-synaptic neurotransmitter pathways, £19507 over 12 months
2011: Dr Evangelia Bakali, University of Leicester; Mechanisms for the coupling of cannabinoid receptors to intracellular calcium mobilization in human and rat bladder, £192,973 over 36 months
We have progressed our understanding of preterm birth and are well on the way to developing innovative new tests and treatments for this often devastating occurrence. We are improving outcomes for babies born preterm Relevant Research:
1986: Miss Gillian Lachelin, University College London; Assessment of the value of measurement of the saliva oestriol: progesterone ratio in the prediction of preterm labour, £19708 over 12 months
1989: Professor Philip James Steer, St Mary’s Hospital Medical School; Prospective randomised trial to compare selective versus elective use of caesarean delivery for the preterm infant in breech presentation, £69792 over 36 months
1990: Dr Theresa Wilson, University of Auckland, Auckland New Zealand; The prediction and control of preterm labour in women, £66311 over 36 months
1990: Dr Steven Thornton, Princess Mary Maternity Hospital, Newcastle upon Tyne; A study of the cellular mechanisms involved in term and preterm labour: Measurement of second messengers in human myometrial cells, £56027 over 24 months
1990: Dr Robert Carr, University of Liverpool; An investigation into molecular underlying defective phagocytosis and killing by neutrophils from preterm infants, £64211 over 36 months
1992: Dr Ronald F Lamont, Northwick Park Hospital; Prevention of late miscarriage and preterm labour by treating abnormal microbial colonisation of the genital tract, £47982 over 24 months
1992: Dr K Chan, University of Nottingham; The role of angiotensin II and calcitonin-gene related peptide receptors in term and preterm labour, £60000 over 12 months
1993: Professor David Taylor, University of Leicester; Studies of the reliability of cervico vaginal onco-fetal fibronectin (ofFN) as a diagnostic and predictive test of preterm birth, £39867 over 12 months
1994: Dr Colin John Morley, University of Cambridge; Development of phase-locked synchronous ventilation for premature babies with respiratory distress syndrome, £65700 over 24 months
1995: Professor Claire Wathes, Royal Vetinary College, London; The role of oxytocin and vasopressin receptors and their steroidal regulation during normal and preterm human labour, £66058 over 24 months
1995: Dr Stephen Bell, University of Leicester; Tenascin isoform expression in human fetal membranes and implications for preterm labour, £79582 over 24 months
1996: Dr Edward Fitzsimmons, Western Infirmary, Glasgow; Ex vivo expansion of umbilical cord haemopoietic progenitor cells for autologous reinfusion to premature neonates, £65,696 over 24 months
1996: Professor Anthony Edwards, Hammersmith Hospital London; Prenatal cerebal injury in preterm infants, £72714 over 24 months
1996: Dr Samir Alvi, The sources and regulation of interleukin-IB production in preterm labour, £61852 over 24 months
1996: Mr Thomas Aitchinson, Universities of Glasgow & Wales/Queen Mother's Hospital; Placento-fetal (autologous) transfusion(PFTx) at birth in infants born preterm: a randomised controlled trial, £35274 over 24 months
1999: Dr John McLaren, University of Leicester; The genesis of fetal membrane rupture by matrix metalloproteinases: implication for the aetiology of preterm birth, £60933 over 24 months
1999: Professor David Edwards, Imperial College at Hammersmith Hospital; Fetoplacental infection and brain injury in extremely preterm infants, £79721 over 24 months
2000: Professor Neil Marlow, Universities of Nottingham and Hertfordshire; The EPICure Study: Assessment of Functional Health Status, Behaviour and Cognitive Outcome of Extremely Preterm Children at Five Years, £69017 over 24 months
2000: Dr Khalid Khan, Universities of York and Birmingham; Systematic quantitative overviews (meta-analyses) of the literature to determine the value of diagnostic tests for predicting preterm birth, £68535 over 18 months
2000: Dr Katie Groom, St. Thomas Hospital and Queen Charlotte's Hospital; Atrial of a COX-2 specific NSAI drug Rofecoxib in prevention of early preterm delivery (TOCOX), £58673 over 18 months
2001: Professor Steven Thornton, University of Warwick; What causes preterm labour? , £79541 over 24 months
2002: Professor Philip Bennett, Imperial College Hammersmith Hospital Campus, London; Inhibition of the nuclear factor kappa B system in prevention of preterm labour, £79475 over 24 months
2008: Dr Lynne Sykes, Imperial College London; New drugs approaches to prevention of preterm birth, £167911 over 36 months
2008: Dr Rashmi Shirbhate, Newcastle University; Origin of cervical cytokines in preterm labour, £14943 over 12 months
2010: Dr Bipasha Chowdhury, EGA Institute for Women's Health; How to factors known to cause preterm premature rupture of the amniotic membranes affect the ultrastructure and integrity of amnion? , £19800 over 12 months
2010: Dr Danielle Abbott, King’s College London; Understanding inflammation in women at risk of preterm birth, £14959 over 12 months
2011: Dr Catherine James, Institute of Women’s Health and Institute of Child Health; The role of cervical innate immunity in preterm birth, £187903 over 24 months
Survival of premature babies can be improved with an artificial version of the natural lung chemical, surfactant, which is routinely used to relieve breathing problems in tiny babies Relevant Research:
1978: Dr Colin J Morley, University of Manchester; Surfactant, a study of its biochemistry, physical properties, and the development of a synthetic surfactant for preventing and treating respiratory distress syndrome, £27550 over 24 months
1981: Dr David Keith James, St Mary’s Hospital, Manchester; Surfactant and Early Onset of Respiratory Failure, £17406 over 24 months
1990: Dr Beverley Jane Randle, University of Bristol; Rapid diagnosis and potential treatment of respiratory distress syndrome by lung surfactant apoprotein analysis, £46473 over 24 months
1994: Dr Colin J Morley, University of Cambridge; Development of phase-locked synchronous ventilation for premature babies with respiratory distress syndrome, £65700 over 24 months
Doctors can now examine and improve the health of babies in the womb by ultrasound scanning, magnetic resonance imaging, heart computer analysis and other innovations Relevant Research:
1973: Mr David Paintin, St. Mary's Hospital Medical School, London; The effects of x-rays and Ultrasound on human germ cells, £500 over 12 months
1974: Mr James Pearson, The Welsh National School of Medicine; Research study of fetal monitoring data; £5700 over 24 months
1974: Prof HC McLaren, University of Birmingham; Research into improvement of fetal monitoring, £21742 over 36 months
1981: Mr David Alan Viniker; Leicester Royal Infirmary and Leicester General Hospital; Fetal Electroencephalography, £15429 over 36 months
1981: Dr Reynir Geirsson, University of Dundee; Evaluation of the Clinical Usefulness of Uterine Volume and Umbilical Blood Flow Measurements by Ultrasound, £24040 over 24 months
1982: Professor Stuart J. Campbell, King’s College Hospital Medical School; Human fetal blood measurement with linear array pulsed doppler duplex, £13523 over 12 months
1984: Professor Edwin W. Symonds, University of Nottingham; Imaging of the feto-placental unit by nuclear magnetic resonance, £26999 over 24 months
1986: Dr Bernard Suart, Coombe-Lying-in Hospital, Dublin; The Dublin Collaborative Trial of Routine Ultrasound in Pregnancy; £39,487 over 24 months
1987: Dr Peter Rolfe, University of Oxford; Continuous monitoring of fetal cerebral oxygenation by near infra-red spectroscopy, £15000 over 12 months
1987: Dr James P. Neilson, University of Glasgow; Prospective Randomised Study of Doppler Waveforms in Umbilical and Uterine Arteries as a Screening method to Identify the Compromised Fetus, £23000 over 24 months
1987: Professor Geoffrey Sharman Dawes, University of Oxford; Computerised antenatel fetal heart rate ( FHR ) in routine clinical practice, £28610 over 24 months
1988: Dr Dulcie Coleman, St. Mary's Medical School London and Queen Charlotte's Maternity Hospital; Evaluation of early amniocentesis for prenatal diagnosis, £37936 over 24 months
1989: Dr Peter Rolfe, University of Oxford; The monitoring of fetal oxygenation by near infra-red spectroscopy, £38954 over 24 months
1989: Dr Theresa Marteau, Royal Free Hospital; Prenatal screening: reducing patient distress, £59749 over 18 months
1992: Mr John Scrimgeour, Western and Eastern General Hospitals, Edinburgh; Detection of fetal genetic abnormality from maternal blood samples, £69517 over 24 months
1992: Dr Jason Gardosi, Queen’s Medical Centre, Nottingham; Clinical evaluation of adjustable fetal growth standards, £51799 over 24 months
1993: Dr Mark Davies, Plymouth General Hospital; Assessment of fetal pulse using an oximetry probe, its use in clinical practice and correlation of oxygen saturation with ST waveform and CTG analysis, £49427 over 24 months
1995: Ms Margaret Ramsay, Queen’s Medical Centre, Nottingham; Doppler ultrasound techniques to investigate the fetal circulation in high risk pregnancies
1996: Mr Demetrios Economides, Royal Free Hospital, London; The first trimester ultrasonographic detection of fetal abnormalities in an unselected population, £58212 over 24 months
1998: Professor Nicholas Fisk, Imperial College at Queen Charlotte's Hospital, London; Selective enrichment and ex vivo expansion of fetal over maternal haemopoietic stem/progenitor cells for non-invasive prenatal diagnosis, £79635 over 24 months
1999: Dr Alec Welsh, Imperial College at Queen Charlotte's Hospital London; Development and validation of novel fetal imaging methods, £89815 over 24 months
2000: Professor Charles Rodeck, University College London; On-line dynamic 3 dimensional echocardiography for prenatal detection of heart malformation and malfunction,£72288 over 24 months
2004: Ms Joy Delhanty, University College London; Detection of Chromosome Anomolies in the First Polar Body by CGH and Validation in the Oocyte and Embryo, £94494 over 24 months
2006: Dr Kelly Cohen, University of Leeds; Use of array comparative genomic hybridisation (CGH) in the investigation of fetal abnormality, £20000 over 12 months
We have a better understanding of why some babies suffer from growth restriction, enabling better treatments for this and for its side-effects Relevant Research:
1985: Professor Murdoch George Elder, University of London; Arachidonic acid metabolism in fetal growth retardation, £27240 over 24 months
1986: Dr David Joseph Hill, University of Sheffield; Somatomedin gene expression and peptide action during human fetal growth, £3048 over 24 months
1991: Professor Peter Howie, University of Dundee; Fetal growth velocity as a predictor of growth retardation and perinatal morbidity, £68652 over 24 months
1992: Dr Jason Gardosi, Queens Medical Centre, Nottingham; Clinical evaluation of adjustable fetal growth standards, £51799 over 24 months
1994: Dr Clive Osmond, Southampton General Hospital; Fetal growth and adult disease in the Dutch famine birth cohort, £58265 over 12 months
1996: Dr Martin Savage, St. Bartholemew's Hospital, London; Study of the growth hormone - insulin-like growth factor-1 (IGF-I) axis and analysis if the IGF-I gene in infants and children with intra-uterine growth retardation, £36460 over 24 months
2000: Dr Gudrun Moore, Queen Charlotte's Hospital; Insulin-like growth factor-2 (IGF2) expression and its effect on fetal growth, £67947 over 24 months
2001: Professor David Dunger, Addenbrookes Hospital, Cambridge; Do the mother's genes affect the size of the baby? £75718 over 24 months
2004: Professor Gudrun Moore, Imperial College London; Placental Specific Insulin-like Growth Factor-2 Expression and its Effect on Fetal Growth, £94720 over 24 months
2004: Mr Khalid Khan, Birmingham Women’s Hospital; The Value of Predicting restriction of Fetal Growth and Compromise of its Wellbeing, £99824 over 24 months
2006: Professor Gudrun Moore, Imperial College London; The role of the H19/IGF2 imprinting pathway in intrauterine growth restriction, £86596 over 24 months
2006: Dr Jennifer Kurinczuk, National Perinatal Epidemiology Unit, University of Oxford; Fetomaternal alloimmune thrombocytopenia (FMAIT): An investigation of the incidence, management and outcomes of affected pregnancies, £22508 over 24 months
2008: Dr Ganeshselvi Premkumar, University of Southampton; The impact of maternal diet on embryo growth and development, £19950 over 12 months
2009: Professor Lesley Regan, Professor Gudrun Moore and collaborators, Imperial College London, Institute of Child Health at University College London, and London maternity units; The Wellbeing of Women Baby Bio Bank, £1500000 over 60 months
2010: Dr Sara Hillman, UCLH Obstetrics and Gynaecology Department; An investigation of phenotypic expression and epigenetic changes to insulin control genes in mothers, fathers and offspring of pregnancies affected by fetal growth restriction, £174282 over 29 months
2011: Dr David Carr, UCL Institute for Womens Health, London; The effect of Ad.VEGF gene therapy in ovine fetal growth restriction on placental structure and function, postnatal metabolism and epigenetic status, £145778 over 24 months
We have a better understanding of HPV enabling more effective screening and treatment Relevant Research:
1986: Dr Henry Charles Kitchener, Glasgow University; Molecular studies of the effects exerted by human papillomavirus infection and the oral steroid contraceptive on the normal human cervix, £27191 over 24 months
1991: Dr David Latchman, University College London; Regulation of papillomavirus gene expression in the normal and malignant cervix by a cervical cell-specific cellular transcription factor, £70000 over 36 months
1992: Dr Karen Vousden, Ludwig Institute for Cancer Research; Identification of genetic alterations which contribute to the development of human papillomavirus associated cervical cancer, £73440 over 36 months
1993: Dr Adekunle Odunsi, University of Oxford; Immunogenetic analysis of HLA Class II antigens in pre-malignant disease of the cervix and their correlation with HPV status, £61968 over 24 months
1993: Dr Elizabeth Adams, University of Liverpool; p53 HPV & epidermal growth factor receptor: do they add prognostic information in cervical carcinoma, £32080 over 12 months
1996: Dr Charles Herrington, University of Liverpool; Karyotypic analysis of cervical neoplasia: chromosome aberrations and human papillomavirus infection, £50933 over 24 months
1998: Dr Margaret Stanley, University of Cambridge; Localisation of a genetic locus on chromosome 10 which regulates expression of the human papillomavirus type 16 oncogene E7, £57091 over 24 months
1998: Professor David Latchman, University College London; Regulation of the HPV- activating transcription factor Brn-3a in normal and malignant cervical cells, £73122 over 24 months
2001: Dr Lynne Hampson, University of Manchester; How does HPV cause cervical cancer and how can HPV be treated? £73338 over 24 months
IVF and other treatments mean millions of people in the UK are freed from the misery of infertility Relevant Research:
1977: Dr Ian David Morris, University of Manchester; An investigation of the antioestrogenic drugs used clinically for the induction of ovulation in infertile women, £9513 over 24 months
1979: Professor Sir John Dewhurst, Institute of Obstetrics and Gynaecology, Chelsea Hospital for Women, University of London; The Significance of antisperm antibodies in Infertile Women,
1982: Dr Elizabeth A Lenton, University of Sheffield; Evaluation of Sub-Clinical Early Pregnancy Wastage as a Cause of persistent Infertility in Otherwise Apparently Normal Couples, £4502 over 12 months 1985: Dr Pamela Vera Taylor, University of Leeds; The Role of Maternal Autoimmunity in Reproductive Failure, £22158 over 24 months
1985: Dr Alison Pamela Murdoch, Royal Victoria Infirmary, Newcastle upon Tyne; A new approach to the analysis of pulsatile secretion of luteinising hormone in normal and infertile subjects, £17523 over 12 months
1985: Dr Lynn R Fraser, Chelsea Hospital for Women; Acrosome loss in human sperm as a measure of fertilizing potential, £18842 over 24 months
1986: Mr Michael Hull, University of Bristol; Fertility Studies Using in-vitro fertilisation, £33366 over 24 months
1986: Dr Rosemary Kill Akhurst, St Mary's Hospital Medical School, University of London; The activity of genes in preimplantation human embryos, £35993 over 24 months
1987: Dr Henry John Leese, University of York; The non-invasive assessment of single pre-implantation mouse embryos, £34649 over 24 months
1987: Dr Lynn R Fraser, RPMS Institute of Obstetrics and Gynaecology; The human sperm acrosome reaction as an indicator of fertilizing potential, £25117 over 24 months 1987: Dr William Ford, University of Bristol; Properties of the plasma membrane of human spermatozoa in relation to cryo-preservation damage, £44504 over 36 months
1987: Dr JD Aplin, University of Manchester; Diagnosis of infertility using a monoclonal antibody to a hormonally regulated endometrial glycoprotein, £18385 over 12 months
1990: Dr Michael Joffe, St Mary’s London; A study of the extent of subfetility in Britain, with validation of research methods, £56890 over 36 months
1991: Dr William Ford, University of Bristol; Changes in intercellular calcium concentration [Ca++]I during cryopreservation of human sprematozoa in relation to the loss of fertility, £73340 over 36 months
1992: Dr Sue Kimber, University of Manchester; Effect of EGF and reproductive steroids in an in vitro model for mammalian implantation, £63972 over 36 months
1992: Professor Max Elstein, University of Manchester; Hormonal regulation of endometrial epithelial function in vitro, £71002 over 24 months
1992: Dr Angus Clarke, University of Wales; Uniparental disomy and reproductive loss, £74998 over 36 months 1992: Dr CLR Barratt, University of Sheffield; The interaction of human spermatozoa with oviductal cells in vitro, £67689 over 36 months
1993: Mr Albert Bernard, University of Wales College of Medicine; Measurement of cell membrane permeabilities to cryoprotective additives in unfertilised human oocytes, £74734 over 36 months
1993: Dr Asif Ahmed, Birmingham Women’s Hospital; Human implantation: the role of bradykinin and phosphatidylcholine hydrolosis, £59652 over 24 months
1994: Dr Isabelle Anne Rooney, University of Wales College of Medicine; The importance of complement regulatory proteins for male fertility, £45816 over 24 months
1994: Dr CLR Barratt, University of Sheffield; The human acrosome reaction characterised with recombinant human zona pellucida protein (rhuZP3), £60009 over 24 months
1995: Dr Adrian Eley, University of Sheffield; The use of molecular methods to detect Chlamydia Trachomatis in female patients with infertility, £37090 over 24 months
1996: Dr Michael Joffe, Imperial College; In utero exposure to tobacco smoke and declining male fertility, £72088 over 24 months
1996: Professor Roger Gosden, University of Leeds; Growth and maturation of human oocytes in vitro, £37164 over 24 months
1998: Dr William Ford, University of Bristol; Sperm lipid peroxidation in the epididymis: evidence of the relationship between ROS, lipid peroxides and abstinence times, £54339 over 24 months
2000: Dr Henry Jabbour, University of Edinburgh; Decidual prolactin and its role in implantation and early pregnancy, £73862 over 24 months
2004: Mr Andy Vail, University of Manchester; Can meta-analysis cope with methodological errors and omissions common in published subfertility intervention studies? £78696 over 36 months
2006: Dr Emily Dickerson, University of Hull; Correlation of somatostatin receptors to the outcome of IVF treatment, £20000 over 12 months
2011: Dr Tom Morewood, Barnet Hospital; Optimization of cryopreservation for ovarian tissue prior to autologous transplantation, £20000 over 12 months
Survival rates for cancer of the womb have improved and we are working towards an effective, simple screening method. We have a better understanding of the causes behind the cancer. Relevant Research:
1985: Professor David T Baird, University of Edinburgh; Aetiology and medical management of uterine leiomyomata, £37603 over 24 months
2008: Dr Ioannis Gallos, Birmingham Women’s NHS Trust; Clinical, morphological and biomarker investigation of endometrial hyperplasia before and following treatment with Levonorgestrel-releasing intrauterine system (LNG-IUS), £17500 over 12 months
2010: Dr Yee-Loi Wan, University of Manchester; Investigating the mechanism that links obesity and uterine cancer, £10375 over 12 months
2010: Dr Nicolas Michel Orsi, Leeds Institute of Molecular Medicine; Eicosanoid networks in endometrial carcinogenesis, £250202 over 30 months