Wellbeing of Women

2001 Grants

What is the role of prostaglandin receptors during pregnancy?
Dr Donna Slater, Prof Steven Thornton & Dr Nicola Woodcock, University of Warwick, £77,227.00 over 24 months. This research has been published in: Mol Hum Reprod. 2007 Jan;13(1):69-75; Mol Hum Reprod. 2006 Feb;12(2):89-97;Mol Hum Reprod. 2005 Apr;11(4):279-87; Mol Hum Reprod. 2004 Nov;10(11):799-805.

A group of hormones, called prostaglandins, are known to be of importance for the onset of labour. Increased prostaglandin levels have been implicated in preterm birth. The action of these prostoglandins is dependent on which prostaglandin receptor is present within a cell. The aim of this study is to understand the role of the receptors in labour so that we are equipped with better information to determine the mechanisms of preterm labour.

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