2000 Grants
Analysis of balanced X: autosome translocation breakpoints in Xq22 from two premature ovarian failure (POF) patients.
Dr Elaine Kendall Molecular, University of Leeds £79,550 over 24 months (2000 - 2001 K1/00)
LAY TITLE: Investigating the genetic causes of premature ovarian failure (POF)
Premature ovarian failure (POF) is a disease where there is a defect in the development of the ovary. It can result in women failing to menstruate at puberty (primary amenorrhoea) or alternatively, menstruation stops prematurely at a younger age than expected (secondary amenorrhoea). POF affects one per cent of women and may originate from a number of different causes.
One of the genetic causes of POF is a defect in one of the woman's two X chromosomes and study will examine a section of this chromosome. It is hoped that, with more understanding of the genes on this chromosome, we will be able to ascertain information vital for the development and maintenance of the ovary.
Wellbeing of Women
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London NW1 4SP
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wellbeingofwomen@rcog.org.uk
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