LAY TITLE: Understanding the mechanisms regulating normal reproductive processes

It is critically important to understand fully how the normal reproductive processes work. Without this fundamental knowledge we cannot offer treatment to women who experience problems such as abnormal periods and early miscarriage. A number of presumed important factors have been identified in the womb lining but precise details about the regulation and roles for many of these, including why an embryo implants in the womb, are still not established.

Prolactin is a substance produced locally in the womb lining in response to exposure to a circulating hormone produced by the ovary (progesterone). This project will utilise modern cell and molecular techniques to establish the consequences of prolactin production by certain cell types in the womb lining. This will be possible by identifying the genes and how they work which are activated in response to exposure to prolactin.

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